Biochemical and Structural Analysis of Helix Pomatia Agglutinin (hpa): a Hexameric Lectin with a Novel Fold*
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چکیده
AGGLUTININ (HPA): A HEXAMERIC LECTIN WITH A NOVEL FOLD* Jean-Frederic Sanchez, Julien Lescar, Valérie Chazalet, Aymeric Audfray, Jean Gagnon, Richard Alvarez, Christelle Breton, Anne Imberty & Edward P. Mitchell From Centre de Recherches sur les Macromolécules Végétales, CNRS (affiliated with Université Joseph Fourier), Grenoble, France, School of Biological Sciences, Nanyang Technological University, Singapore, CNRS-FRE2685, Université Joseph Fourier, La Tronche, France, Dept. Biochem/Mol. Biol. University of Oklahoma, USA, E.S.R.F. Experiments Division, Grenoble, France Running Title: Crystal structure of Helix pomatia lectin Address correspondence to Anne Imberty, CERMAV-CNRS BP53, 38041 Grenoble cedex 09, France ; Fax: +33-476547203; E-Mail: [email protected] or Edward P. Mitchel E.S.R.F. Experiments Division, BP 220, F-38043, Grenoble Cedex, France; Fax : ++33476882542; E-Mail: [email protected]
منابع مشابه
Biochemical and structural analysis of Helix pomatia agglutinin. A hexameric lectin with a novel fold.
Helix pomatia agglutinin (HPA) is a N-acetylgalactosamine (GalNAc) binding lectin found in the albumen gland of the roman snail. As a constituent of perivitelline fluid, HPA protects fertilized eggs from bacteria and is part of the innate immunity system of the snail. The peptide sequence deduced from gene cloning demonstrates that HPA belongs to a family of carbohydrate-binding proteins recent...
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